Molecular and Bimolecular engineering - Research

Research in the laboratory focuses on the understanding and characterization of interactions between molecular units using various physico-chemical methods (micro-calorimetry; NMR spectroscopy and circular dichroïsm). We are interested in the stability and dynamics of biomolecules and in the association complexes that they form with other (bio)molecules. The understanding of the energetics that guide the selective association of proteins and DNA with other (bio)molecules including water, ligands or hormones is of fundamental importance in bio-nanotechnology, for the development of therapeutic agents and diagnostic tools. We are also involved in the development of synthetic receptors or, in general, of synthetic building blocks that can selectively interact in water with a given substrate. The analytical detection and monitoring in aqueous environments of compounds present at extremely low concentrations is a subject of great current interest in medical diagnostics.

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